TRPV2

TRPV2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2F37
Identifiers
Aliases	TRPV2, VRL, VRL-1, VRL1, transient receptor potential cation channel subfamily V member 2
External IDs	OMIM: 606676; MGI: 1341836; HomoloGene: 7993; GeneCards: TRPV2; OMA:TRPV2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	16,437,003 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	62,491,341 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; upper lobe of left lung; ; spleen; ; blood; ; right coronary artery; ; right lung; ; monocyte; ; right adrenal gland; ; right adrenal cortex; ; left coronary artery;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; facial motor nucleus; ; thymus; ; stroma of bone marrow; ; mesenteric lymph nodes; ; blood; ; spleen; ; calvaria; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion transmembrane transporter activity; ion channel activity; cation channel activity; calcium channel activity;
Cellular component	cytoplasm; integral component of membrane; cell body; membrane; melanosome; plasma membrane; growth cone membrane; axonal growth cone; integral component of plasma membrane; intracellular anatomical structure; cell surface; axon;
Biological process	sensory perception; response to heat; ion transport; positive regulation of calcium ion import; calcium ion transmembrane transport; positive regulation of axon extension; response to temperature stimulus; calcium ion transport; transmembrane transport; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	51393
	22368
	ENSG00000187688
	ENSMUSG00000018507
	Q9Y5S1
	Q9WTR1
	NM_016113
	NM_011706; NM_001382489; NM_001382490; NM_001382491; NM_001382492
	NP_057197
	NP_035836; NP_001369418; NP_001369419; NP_001369420; NP_001369421
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel subfamily V member 2 is a protein that in humans is encoded by the TRPV2 gene.^[5]^[6] TRPV2 is a nonspecific cation channel that is a part of the TRP channel family. This channel allows the cell to communicate with its extracellular environment through the transfer of ions, and responds to noxious temperatures greater than 52 °C. It has a structure similar to that of potassium channels, and has similar functions throughout multiple species; recent research has also shown multiple interactions in the human body.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187688 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018507 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (April 1999). "A capsaicin-receptor homologue with a high threshold for noxious heat". Nature. 398 (6726): 436–41. Bibcode:1999Natur.398..436C. doi:10.1038/18906. PMID 10201375. S2CID 4415522.
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187688 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018507 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10201375-5] Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (April 1999). "A capsaicin-receptor homologue with a high threshold for noxious heat". Nature. 398 (6726): 436–41. Bibcode:1999Natur.398..436C. doi:10.1038/18906. PMID 10201375. S2CID 4415522.

[pmid16382100-6] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

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