TRPV3

TRPV3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4N5Q
Identifiers
Aliases	TRPV3, FNEPPK2, OLMS, VRL3, transient receptor potential cation channel subfamily V member 3, OLMS1
External IDs	OMIM: 607066; MGI: 2181407; HomoloGene: 17040; GeneCards: TRPV3; OMA:TRPV3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,557,812 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	73,191,189 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; sural nerve; ; testicle; ; gonad; ; bone marrow cells; ; C1 segment; ; Brodmann area 9; ; right frontal lobe; ; rectum;
	Top expressed in
	lip; ; zone of skin; ; secondary oocyte; ; primary oocyte; ; esophagus; ; vasculature; ; vasculature of organ; ; zygote; ; temporal lobe; ; colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	ion channel activity; cation channel activity; calcium channel activity;
Cellular component	integral component of membrane; receptor complex; plasma membrane; membrane; integral component of plasma membrane;
Biological process	positive regulation of calcium ion import; response to heat; ion transport; calcium ion transmembrane transport; calcium ion transport; negative regulation of hair cycle; response to temperature stimulus; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	162514
	246788
	ENSG00000167723
	ENSMUSG00000043029
	Q8NET8
	Q8K424
	NM_001258205; NM_145068
	NM_145099; NM_001371006
	NP_001245134; NP_659505
	NP_659567; NP_001357935
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel, subfamily V, member 3, also known as TRPV3, is a human gene encoding the protein of the same name.

The TRPV3 protein belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of human sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. The gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167723 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043029 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TRPV3 transient receptor potential cation channel, subfamily V, member 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167723 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043029 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: TRPV3 transient receptor potential cation channel, subfamily V, member 3".

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