TRPV4

TRPV4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRPV4, BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC, transient receptor potential cation channel subfamily V member 4
External IDsOMIM: 605427; MGI: 1926945; HomoloGene: 11003; GeneCards: TRPV4; OMA:TRPV4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

59341

63873

Ensembl

ENSG00000111199

ENSMUSG00000014158

UniProt

Q9HBA0

Q9EPK8

RefSeq (mRNA)

NM_001177428
NM_001177431
NM_001177433
NM_021625
NM_147204

NM_022017

RefSeq (protein)

NP_001170899
NP_001170902
NP_001170904
NP_067638
NP_671737

NP_071300

Location (UCSC)Chr 12: 109.78 – 109.83 MbChr 5: 114.76 – 114.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transient receptor potential cation channel subfamily V member 4 is an ion channel protein that in humans is encoded by the TRPV4 gene.

The TRPV4 gene encodes TRPV4, initially named "vanilloid-receptor related osmotically activated channel" (VR-OAC) and "OSM9-like transient receptor potential channel, member 4 (OTRPC4)",[5][6] a member of the vanilloid subfamily in the transient receptor potential (TRP) superfamily of ion channels.[7][8][9] The encoded protein is a Ca2+-permeable, nonselective cation channel that has been found involved in multiple physiologic functions, dysfunctions and also disease. It functions in the regulation of systemic osmotic pressure by the brain, in vascular function, in liver, intestinal, renal and bladder function, in skin barrier function and response of the skin to ultraviolet-B radiation, in growth and structural integrity of the skeleton, in function of joints, in airway- and lung function, in retinal and inner ear function, and in pain. The channel is activated by osmotic, mechanical and chemical cues. It also responds to thermal changes (warmth). Channel activation can be sensitized by inflammation and injury.

The TRPV4 gene has been co-discovered by W. Liedtke et al.[5] and R. Strotmann et al.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111199 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014158 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Liedtke W, Choe Y, Martí-Renom MA, Bell AM, Denis CS, Sali A, et al. (October 2000). "Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor". Cell. 103 (3): 525–535. doi:10.1016/S0092-8674(00)00143-4. PMC 2211528. PMID 11081638.
  6. ^ a b Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD (October 2000). "OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity". Nature Cell Biology. 2 (10): 695–702. doi:10.1038/35036318. PMID 11025659. S2CID 21148080.
  7. ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–450. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
  8. ^ Harteneck C, Plant TD, Schultz G (April 2000). "From worm to man: three subfamilies of TRP channels". Trends in Neurosciences. 23 (4): 159–166. doi:10.1016/S0166-2236(99)01532-5. PMID 10717675. S2CID 41074873.
  9. ^ Plant TD, Strotmann R (2007). "TRPV4". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. Vol. 179. pp. 189–205. doi:10.1007/978-3-540-34891-7_11. ISBN 978-3-540-34889-4. PMID 17217058.