TSC2

TSC2
Identifiers
Aliases	TSC2, LAM, PPP1R160, TSC4, tuberous sclerosis 2, TSC complex subunit 2
External IDs	OMIM: 191092; MGI: 102548; HomoloGene: 462; GeneCards: TSC2; OMA:TSC2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,089,491 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,851,604 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; anterior pituitary; ; right uterine tube; ; right lobe of thyroid gland; ; sural nerve; ; left lobe of thyroid gland; ; right testis; ; left testis; ; right frontal lobe; ; left ovary;
	Top expressed in
	tail of embryo; ; genital tubercle; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; neural layer of retina; ; muscle of thigh; ; cardiac muscle tissue of left ventricle; ; ventricular zone; ; CA3 field;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatase binding; protein homodimerization activity; GTPase activator activity; small GTPase binding; protein binding; Hsp90 protein binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; membrane; TSC1-TSC2 complex; perinuclear region of cytoplasm; lysosome; nucleus; postsynaptic density;
Biological process	regulation of endocytosis; protein localization; insulin-like growth factor receptor signaling pathway; negative regulation of protein kinase B signaling; endocytosis; protein import into nucleus; negative regulation of protein kinase activity; negative regulation of Wnt signaling pathway; negative regulation of phosphatidylinositol 3-kinase signaling; regulation of cell cycle; heart development; positive regulation of GTPase activity; neural tube closure; negative regulation of insulin receptor signaling pathway; positive chemotaxis; viral process; regulation of small GTPase mediated signal transduction; vesicle-mediated transport; negative regulation of cell population proliferation; regulation of insulin receptor signaling pathway; positive regulation of macroautophagy; anoikis; negative regulation of mitophagy; negative regulation of TOR signaling; protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	7249
	22084
	ENSG00000103197
	ENSMUSG00000002496
	P49815
	Q61037
NM_000548; NM_001077183; NM_001114382; NM_021055; NM_021056;
	NM_001318827; NM_001318829; NM_001318831; NM_001318832; NM_001363528; NM_001370404; NM_001370405
NM_001039363; NM_001286713; NM_001286714; NM_001286716; NM_001286718;
	NM_001286720; NM_011647
NP_000539; NP_001070651; NP_001107854; NP_001305756; NP_001305758;
	NP_001305760; NP_001305761; NP_066399; NP_001350457; NP_001357333; NP_001357334
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Tuberous sclerosis complex 2 (TSC2), also known as tuberin, is a protein that in humans is encoded by the TSC2 gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103197 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002496 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103197 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002496 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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