TSPAN6

TSPAN6
Identifiers
Aliases	TSPAN6, T245, TM4SF6, TSPAN-6, tetraspanin 6
External IDs	OMIM: 300191; MGI: 1926264; HomoloGene: 20700; GeneCards: TSPAN6; OMA:TSPAN6 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	100,639,991 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	132,799,178 bp
RNA expression pattern
	Top expressed in
	sperm; ; parotid gland; ; bronchial epithelial cell; ; nasal epithelium; ; epithelium of nasopharynx; ; tibia; ; mucosa of paranasal sinus; ; olfactory zone of nasal mucosa; ; mucosa of colon; ; mucosa of sigmoid colon;
	Top expressed in
	saccule; ; transitional epithelium of urinary bladder; ; otic placode; ; otic vesicle; ; endocardial cushion; ; atrioventricular valve; ; medial ganglionic eminence; ; molar; ; abdominal wall; ; neural tube;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity;
Cellular component	integral component of membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of NIK/NF-kappaB signaling; cell surface receptor signaling pathway; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7105
	56496
	ENSG00000000003
	ENSMUSG00000067377
	O43657
	O70401
	NM_001278740; NM_001278741; NM_001278742; NM_001278743; NM_003270
	NM_019656
	NP_001265669; NP_001265670; NP_001265671; NP_001265672; NP_003261
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.^[5]^[6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2. The use of alternate polyadenylation sites has been found for this gene.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000000003 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067377 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maeda K, Matsuhashi S, Hori K, Xin Z, Mukai T, Tabuchi K, Egashira M, Niikawa N (Dec 1998). "Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22". Genomics. 52 (2): 240–2. doi:10.1006/geno.1998.5415. PMID 9782095.
^ ^a ^b "Entrez Gene: TSPAN6 tetraspanin 6".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000000003 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067377 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9782095-5] Maeda K, Matsuhashi S, Hori K, Xin Z, Mukai T, Tabuchi K, Egashira M, Niikawa N (Dec 1998). "Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22". Genomics. 52 (2): 240–2. doi:10.1006/geno.1998.5415. PMID 9782095.

[entrez-6] "Entrez Gene: TSPAN6 tetraspanin 6".

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