TSPAN7

TSPAN7
Identifiers
Aliases	TSPAN7, A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, TALLA-1, TM4SF2, TM4SF2b, tetraspanin 7, XLID58
External IDs	OMIM: 300096; MGI: 1298407; HomoloGene: 20967; GeneCards: TSPAN7; OMA:TSPAN7 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	38,688,920 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	10,462,844 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; nucleus accumbens; ; dorsolateral prefrontal cortex; ; prefrontal cortex; ; putamen; ; right frontal lobe; ; Brodmann area 9; ; cerebellar cortex; ; frontal pole; ; cerebellar hemisphere;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; superior frontal gyrus; ; primary visual cortex; ; nucleus of stria terminalis; ; primary motor cortex; ; dorsal striatum; ; prefrontal cortex;
	More reference expression data
	More reference expression data
Orthologs
	7102
	21912
	ENSG00000156298
	ENSMUSG00000058254
	P41732
	Q62283
	NM_004615
	NM_019634
	NP_004606
	NP_062608
	Wikidata
View/Edit Human	View/Edit Mouse

Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene.^[5]^[6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy.^[6] More recently, it has been identified as a key immune system target in type 1 diabetes.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156298 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058254 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Abidi FE, Holinski-Feder E, Rittinger O, Kooy F, Lubs HA, Stevenson RE, Schwartz CE (Jun 2002). "A novel 2 bp deletion in the TM4SF2 gene is associated with MRX58". J Med Genet. 39 (6): 430–3. doi:10.1136/jmg.39.6.430. PMC 1735161. PMID 12070254.
^ ^a ^b "Entrez Gene: TSPAN7 tetraspanin 7".
^ McLaughlin, KA; Richardson, CC (16 March 2016). "Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes". Diabetes. 65 (6): 1690–8. doi:10.2337/db15-1058. PMID 26953162.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156298 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058254 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12070254-5] Abidi FE, Holinski-Feder E, Rittinger O, Kooy F, Lubs HA, Stevenson RE, Schwartz CE (Jun 2002). "A novel 2 bp deletion in the TM4SF2 gene is associated with MRX58". J Med Genet. 39 (6): 430–3. doi:10.1136/jmg.39.6.430. PMC 1735161. PMID 12070254.

[entrez-6] "Entrez Gene: TSPAN7 tetraspanin 7".

[Diabetes-7] McLaughlin, KA; Richardson, CC (16 March 2016). "Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes". Diabetes. 65 (6): 1690–8. doi:10.2337/db15-1058. PMID 26953162.

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