Ta3a

Delta-myrmicitoxin-Ta3a
Ta3a structure prediction from AlphaFold
Identifiers
OrganismTetramorium africanum
Symbol?
UniProtP0DX61
Search for
StructuresSwiss-model
DomainsInterPro
Ta3a
Identifiers
3D model (JSmol)
  • InChI=1S/C159H248N36O38/c1-26-89(20)129(155(229)175-105(55-57-128(204)205)138(212)173-103(43-35-36-58-160)137(211)186-118(75-126(164)202)149(223)184-116(72-98-48-52-101(199)53-49-98)151(225)192-130(90(21)27-2)156(230)176-106(132(165)206)74-125(163)201)191-150(224)115(71-97-46-50-100(198)51-47-97)183-148(222)117(73-99-76-166-80-168-99)185-139(213)104(54-56-124(162)200)174-142(216)108(63-83(8)9)177-134(208)93(24)170-153(227)122-44-38-60-195(122)159(233)119(68-88(18)19)188-152(226)121(79-197)190-147(221)114(70-96-41-33-30-34-42-96)182-141(215)107(62-82(6)7)172-127(203)77-167-136(210)120(78-196)189-146(220)112(67-87(16)17)181-145(219)111(66-86(14)15)180-144(218)110(65-85(12)13)179-143(217)109(64-84(10)11)178-133(207)92(23)169-140(214)113(69-95-39-31-29-32-40-95)187-157(231)131(91(22)28-3)193-154(228)123-45-37-59-194(123)158(232)94(25)171-135(209)102(161)61-81(4)5/h29-34,39-42,46-53,76,80-94,102-123,129-131,196-199H,26-28,35-38,43-45,54-75,77-79,160-161H2,1-25H3,(H2,162,200)(H2,163,201)(H2,164,202)(H2,165,206)(H,166,168)(H,167,210)(H,169,214)(H,170,227)(H,171,209)(H,172,203)(H,173,212)(H,174,216)(H,175,229)(H,176,230)(H,177,208)(H,178,207)(H,179,217)(H,180,218)(H,181,219)(H,182,215)(H,183,222)(H,184,223)(H,185,213)(H,186,211)(H,187,231)(H,188,226)(H,189,220)(H,190,221)(H,191,224)(H,192,225)(H,193,228)(H,204,205)/t89-,90-,91-,92-,93-,94-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,129-,130-,131-/m0/s1
    Key: IAQFHRWWIJXKQC-SWRHZYTASA-N
  • N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N
Properties
C159H248N36O38
Molar mass 3271.947 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Ta3a (Delta-myrmicitoxin-Ta3a) is a vertebrate-selective neurotoxin found in the venom of the African ant species Tetramorium africanum. It is known to cause intense, long-lasting pain by targeting voltage-gated sodium channels in peripheral sensory neurons. Ta3a strongly reduces sodium channel inactivation, leading to heightened neuronal excitability.