Tachykinin receptor 1

TACR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KSB, 2KS9, 2KSA
Identifiers
Aliases	TACR1, NK1R, NKIR, SPR, TAC1R, tachykinin receptor 1
External IDs	OMIM: 162323; MGI: 98475; HomoloGene: 20288; GeneCards: TACR1; OMA:TACR1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p12 Start 75,046,463 bp[1] End 75,199,520 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 82,379,315 bp[2] End 82,537,085 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle canal of the cervix subcutaneous adipose tissue ectocervix body of uterus left uterine tube tendon of biceps brachii Achilles tendon smooth muscle tissue vagina Top expressed in main bronchus lens superior frontal gyrus trachea thyroid gland neural layer of retina ventricular zone stomach neural tube primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function tachykinin receptor activity G protein-coupled receptor activity signal transducer activity protein binding substance P receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane cell periphery cytoplasm cell surface dendrite cell body sperm flagellum sperm head sperm midpiece Biological process regulation of uterine smooth muscle contraction phospholipase C-activating G protein-coupled receptor signaling pathway response to pain detection of abiotic stimulus inflammatory response positive regulation of smooth muscle contraction signal transduction chemical synaptic transmission aggressive behavior acute inflammatory response positive regulation of leukocyte migration angiotensin-mediated drinking behavior learning or memory long-term memory regulation of blood pressure associative learning response to heat response to hormone response to ozone positive regulation of epithelial cell migration response to auditory stimulus response to organic cyclic compound regulation of smooth muscle cell migration sensory perception of pain positive regulation of synaptic transmission, cholinergic positive regulation of synaptic transmission, GABAergic response to estradiol response to progesterone response to nicotine operant conditioning positive regulation of renal sodium excretion ejaculation eating behavior positive regulation of vascular permeability response to morphine response to ethanol positive regulation of action potential positive regulation of blood pressure positive regulation of ossification positive regulation of vasoconstriction positive regulation of saliva secretion positive regulation of hormone secretion behavioral response to pain regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation positive regulation of epithelial cell proliferation positive regulation of stress fiber assembly response to electrical stimulus smooth muscle contraction involved in micturition positive regulation of uterine smooth muscle contraction positive regulation of cytosolic calcium ion concentration tachykinin receptor signaling pathway positive regulation of flagellated sperm motility G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6869 21336 Ensembl ENSG00000115353 ENSMUSG00000030043 UniProt P25103 P30548 RefSeq (mRNA) NM_015727 NM_001058 NM_009313 RefSeq (protein) NP_001049 NP_056542 NP_033339 Location (UCSC) Chr 2: 75.05 – 75.2 Mb Chr 6: 82.38 – 82.54 Mb PubMed search [3] [4]
Wikidata
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The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene.^[5]