Tchoupitoulas Street (/ˌtʃɒpɪˈtuːləs/ CHOP-ih-TOO-ləss) is a street in New Orleans, Louisiana, United States. Running through uptown, it is the through street closest to the Mississippi River. Formerly, the street was heavily devoted to river shipping commerce, but as shipping concerns gravitated to other locations in the latter part of the 20th century, more of the street has been utilized for residential and other business purposes.