Technetium (99mTc) sestamibi

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Technetium (99mTc) sestamibi" – news · newspapers · books · scholar · JSTOR (June 2011) (Learn how and when to remove this message)

Technetium (^99mTc) sestamibi

Clinical data
Trade names	Cardiolite
License data	US FDA: TECHNETIUM_TC-99M_SESTAMIBI_KIT
Routes of administration	Intravenous
ATC code	V09GA01 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	NA
Protein binding	1%
Metabolism	Nil
Elimination half-life	Variable
Excretion	Fecal (33%) and renal (27%)
Identifiers
IUPAC name Hexakis(2-methoxy-2-methylpropylisonitrile) technetium (99mTc)
CAS Number	109581-73-9 Y
PubChem CID	5384
ChemSpider	396214
UNII	971Z4W1S09
KEGG	D01060
ChEBI	CHEBI:9423
CompTox Dashboard (EPA)	DTXSID00911248
Chemical and physical data
Formula	C36H66N6O6Tc
Molar mass	777 g·mol−1
3D model (JSmol)	Interactive image
SMILES [99Tc-5](C#[N+]CC(C)(C)OC)(C#[N+]CC(C)(C)OC)(C#[N+]CC(C)(C)OC)(C#[N+]CC(C)(C)OC)(C#[N+]CC(C)(C)OC)C#[N+]CC(C)(C)OC
(verify)

Technetium (^99mTc) sestamibi (INN) (commonly sestamibi; USP: technetium Tc 99m sestamibi; trade name Cardiolite) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six (sesta=6) methoxyisobutylisonitrile (MIBI) ligands. The anion is not defined. The generic drug became available late September 2008. A scan of a patient using MIBI is commonly known as a "MIBI scan".

Sestamibi is taken up by tissues with large numbers of mitochondria and negative plasma membrane potentials.^[1] Sestamibi is mainly used to image the myocardium (heart muscle). It is also used in the work-up of primary hyperparathyroidism to identify parathyroid adenomas, for radioguided surgery of the parathyroid and in the work-up of possible breast cancer.