Terconazole

Terconazole

Clinical data
Trade names	Terazol
AHFS/Drugs.com	Monograph
MedlinePlus	a688022
ATC code	G01AG02 (WHO)
Pharmacokinetic data
Protein binding	94.9%
Identifiers
IUPAC name 1-[4-[ [(2S,4S)-2-(2,4-Dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-yl-piperazine
CAS Number	67915-31-5 Y
PubChem CID	441383
DrugBank	DB00251 Y
ChemSpider	390122 Y
UNII	0KJ2VE664U
KEGG	D00888 Y
ChEBI	CHEBI:9451 N
ChEMBL	ChEMBL1306 Y
CompTox Dashboard (EPA)	DTXSID2045498
ECHA InfoCard	100.061.573
Chemical and physical data
Formula	C26H31Cl2N5O3
Molar mass	532.47 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1ccc(c(Cl)c1)[C@@]4(O[C@@H](COc3ccc(N2CCN(C(C)C)CC2)cc3)CO4)Cn5ncnc5
InChI InChI=1S/C26H31Cl2N5O3/c1-19(2)31-9-11-32(12-10-31)21-4-6-22(7-5-21)34-14-23-15-35-26(36-23,16-33-18-29-17-30-33)24-8-3-20(27)13-25(24)28/h3-8,13,17-19,23H,9-12,14-16H2,1-2H3/t23-,26-/m0/s1 Y Key:BLSQLHNBWJLIBQ-OZXSUGGESA-N Y
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Terconazole is an antifungal drug used to treat vaginal yeast infection. It comes as a lotion or a suppository and disrupts the biosynthesis of fats in a yeast cell. It has a relatively broad spectrum compared to azole compounds but not triazole compounds. Testing shows that it is a suitable compound for prophylaxis for those that suffer from chronic vulvovaginal candidiasis.