Testicular receptor 2

NR2C1
Identifiers
Aliases	NR2C1, TR2, Testicular receptor 2, nuclear receptor subfamily 2 group C member 1
External IDs	OMIM: 601529; MGI: 1352465; HomoloGene: 55731; GeneCards: NR2C1; OMA:NR2C1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	95,073,628 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	94,033,073 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; left lobe of thyroid gland; ; right lung; ; tibial nerve; ; muscle of thigh; ; sural nerve; ; right lobe of thyroid gland; ; right lobe of liver; ; gastric mucosa;
	Top expressed in
	spermatid; ; spermatocyte; ; seminal vesicula; ; corneal stroma; ; otic vesicle; ; male urethra; ; secondary oocyte; ; genital tubercle; ; seminiferous tubule; ; tail of embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; protein homodimerization activity; DNA-binding transcription factor activity; zinc ion binding; histone deacetylase binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; steroid hormone receptor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; signaling receptor activity;
Cellular component	PML body; nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; negative regulation of transcription, DNA-templated; steroid hormone mediated signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7181
	22025
	ENSG00000120798
	ENSMUSG00000005897
	P13056
	Q505F1
	NM_001032287; NM_001127362; NM_003297
	NM_011629
	NP_001027458; NP_001120834; NP_003288; NP_003288.2
	NP_035759
	Wikidata
View/Edit Human	View/Edit Mouse

The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1 gene.^[5]^[6] TR2 is a member of the nuclear receptor family of transcription factors.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120798 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005897 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1".
^ Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (Dec 1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochemical and Biophysical Research Communications. 165 (2): 735–41. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120798 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005897 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1".

[pmid2597158-6] Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (Dec 1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochemical and Biophysical Research Communications. 165 (2): 735–41. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.

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