Testolactone

Testolactone
Clinical data
Trade names	Teslac
Other names	13-Hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid δ-lactone; SQ-9538; Fludestrin; NSC-12173; NSC-23759
AHFS/Drugs.com	Consumer Drug Information
Routes of; administration	By mouth
Drug class	Aromatase inhibitor; Antiestrogen
ATC code	none;
Pharmacokinetic data
Protein binding	~85%
Metabolism	Liver
Excretion	Urine
Identifiers
	IUPAC name (4aS,4bR,10aR,10bS,12aS)-10a,12a-Dimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydro-2H-naphtho[2,1-f]chromene-2,8(4bH)-dione;
CAS Number	968-93-4 ;
PubChem CID	13769;
IUPHAR/BPS	7303;
DrugBank	DB00894 ;
ChemSpider	13172 ;
UNII	6J9BLA949Q;
KEGG	D00153 ;
ChEBI	CHEBI:9460 ;
ChEMBL	ChEMBL1571 ;
CompTox Dashboard (EPA)	DTXSID2023644 ;
ECHA InfoCard	100.012.304
Chemical and physical data
Formula	C19H24O3
Molar mass	300.398 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC12CCC3C(C1CCC(=O)O2)CCC4=CC(=O)C=CC34C;
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Testolactone (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name) (brand name Teslac) is a non-selective, irreversible, steroidal aromatase inhibitor which is used as an antineoplastic drug to treat advanced-stage breast cancer.^[1]^[2]^[3]^[4] The drug was discontinued in 2008 and is no longer available for medical use.^[4]^[5]

^ Milne GW (8 May 2018). Drugs: Synonyms and Properties: Synonyms and Properties. Taylor & Francis. pp. 935–. ISBN 978-1-351-78989-9.
^ Testolactone at DrugBank.ca
^ Dunkel L (July 2006). "Use of aromatase inhibitors to increase final height". Molecular and Cellular Endocrinology. 254–255: 207–216. doi:10.1016/j.mce.2006.04.031. PMID 16766117. S2CID 34706246.
^ ^a ^b Cite error: The named reference LemkeWilliams2012 was invoked but never defined (see the help page).
^ "Testolactone Advanced Patient Information". Drugs.com. 2022-03-19. Retrieved 2022-07-21.