Tetra-amelia syndrome

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Tetra-amelia syndrome
Other names	Autosomal recessive tetraamelia
Violetta, a 1920s sideshow performer with tetra-amelia syndrome

Tetra-amelia syndrome (tetra- + amelia), also called autosomal recessive tetraamelia,^[1] is an extremely rare autosomal recessive^[2] congenital disorder characterized by the absence of all four limbs. Other areas of the body are also affected by malformations, such as the face, skull, reproductive organs, anus, lungs and pelvis.^[1] The disorder can be caused by recessive mutations in the WNT3 or RSPO2 genes.^[2][3]