The Last Man is an 1826 science fiction novel by Mary Shelley
The Last Man or Last Man may also refer to:
- Last man, a term used by Nietzsche to describe the antithesis of the Übermensch
- The Last Man (1932 film), an American film directed by Howard Higgin
- The Last Man (1934 film), a Czech comedy film directed by Martin Frič
- The Last Man (1955 film), a West German film
- The Last Man (2002 film), an American film directed by Harry Ralston
- The Last Man (2006 film), a Lebanese film
- The Last Man (2019 film), a Canadian film starring Hayden Christensen and Harvey Keitel
- "The Last Man" (Stargate Atlantis), an episode of Stargate Atlantis
- Last man (football), the last team member in a position to stop an obvious goal-scoring opportunity
- Lastman (comic book), a French comics series