Thiazolidinedione

Functional group

The thiazolidinediones /θaɪ.əˌzoʊlɪdiːnˈdaɪ.oʊn/, abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone,[1] are a class of heterocyclic compounds consisting of a five-membered C3NS ring. The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 that were introduced in the late 1990s. As of 2024, there are two FDA-approved drugs in this class, pioglitazone and rosiglitazone.[2]

  1. ^ Hulin B, McCarthy PA, Gibbs EM (1996). "The glitazone family of antidiabetic agents". Current Pharmaceutical Design. 2: 85–102. doi:10.2174/1381612802666220920215821. S2CID 252485570.
  2. ^ Eggleton, Julie S.; Jialal, Ishwarlal (2024), "Thiazolidinediones", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 31869120, retrieved 20 September 2024