Thiethylperazine

Thiethylperazine
Clinical data
Trade names	Torecan, Norzine
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	R06AD03 (WHO) ;
Pharmacokinetic data
Protein binding	60%
Identifiers
	IUPAC name 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine;
CAS Number	1420-55-9 ;
PubChem CID	5440;
IUPHAR/BPS	7306;
DrugBank	DB00372 ;
ChemSpider	5245 ;
UNII	8ETK1WAF6R;
KEGG	D02354 ;
ChEBI	CHEBI:9544 ;
ChEMBL	ChEMBL1378 ;
CompTox Dashboard (EPA)	DTXSID1023651 ;
ECHA InfoCard	100.014.381
Chemical and physical data
Formula	C22H29N3S2
Molar mass	399.62 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES S(c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4)CC;
	InChI InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3 ; Key:XCTYLCDETUVOIP-UHFFFAOYSA-N ;
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Thiethylperazine (Torecan, Norzine) is an antiemetic^[1] of the phenothiazine class. It is an antagonist of dopamine receptors (DRD1, DRD2, DRD4) as well as of 5-HT_2A, 5-HT_2C receptors, mAChRs (1 through 5), α₁ adrenergic receptor and H₁ receptor.

Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice.^[2]

^ Tamboline BL, Mcgillivray DC, Bogoch A (February 1965). "The Effects of Thiethylperazine Dimaleate (Torecan) on Nausea and Vomiting". Canadian Medical Association Journal. 92 (8): 422–423. PMC 1928133. PMID 14261157.
^
Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, et al. (October 2011). "Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice". The Journal of Clinical Investigation. 121 (10): 3924–3931. doi:10.1172/JCI57867. PMC 3195473. PMID 21881209.
- "Alzheimer disease: Transport protein ABCC1 plays key role in clearing beta-amyloid from brains of mice". ScienceDaily (Press release). September 1, 2011.