Thomas Little (1886–1985) was a Hollywood set decorator.
Thomas Little may also refer to:
- Thomas Little, pseudonym of publisher John Joseph Stockdale
- Thomas Little (Windsor MP), British Member of Parliament for Windsor
- Sir Frank Little (bishop) (Thomas Francis Little, 1925–2008), Roman Catholic Archbishop of Melbourne
- Thomas Shepherd Little, British Member of Parliament for Whitehaven
- Tom Little (optometrist) (died 2010), American optometrist killed in Afghanistan
- Tom Little (cartoonist) (1898–1972), Pulitzer Prize–winning editorial cartoonist
- Tommy Little (footballer, born 1872) (1872–?), Scottish footballer for Barnsley, Derby County, Luton Town and Manchester City
- Tommy Little (footballer, born 1890) (1890–1927), English footballer for Bradford Park Avenue and Stoke
- Tommy Little (comedian), Australian comedian, writer, actor, and presenter