Thomas Murphy (1821 – August 17, 1901) was an Irish-American businessman and politician from New York City, serving as a New York state senator for a total of three terms, 1866 through 1867, and in 1879. He had joined the Republican Party and made his fortune selling equipment to the Union Army during the American Civil War. Afterward, he became part of the political machine run by US Senator from New York Roscoe Conkling, and was appointed as the Collector of the Port of New York from 1870 to 1871.