Thrombopoietin

THPO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V7M, 1V7N
Identifiers
Aliases	THPO, MGDF, MKCSF, ML, MPLLG, THCYT1, TPO, thrombopoietin
External IDs	OMIM: 600044; MGI: 101875; HomoloGene: 398; GeneCards: THPO; OMA:THPO - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 184,371,935 bp[1] End 184,381,968 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B1|16 12.51 cM Start 20,543,204 bp[2] End 20,553,261 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right hemisphere of cerebellum right frontal lobe body of uterus cingulate gyrus anterior cingulate cortex Brodmann area 9 right adrenal gland canal of the cervix right ovary Top expressed in muscle of thigh right kidney yolk sac primary visual cortex proximal tubule embryo embryo tail of embryo superior frontal gyrus left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity growth factor activity hormone activity signaling receptor binding Cellular component extracellular region extracellular space Biological process multicellular organism development positive regulation of hematopoietic stem cell proliferation cell population proliferation regulation of signaling receptor activity positive regulation of protein phosphorylation thrombopoietin-mediated signaling pathway positive regulation of megakaryocyte differentiation positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade positive regulation of cell population proliferation myeloid cell differentiation megakaryocyte development positive regulation of MAPK cascade receptor signaling pathway via STAT Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7066 21832 Ensembl ENSG00000090534 ENSMUSG00000022847 UniProt P40225 P40226 RefSeq (mRNA) NM_000460 NM_001177597 NM_001177598 NM_001289997 NM_001289998 NM_001290003 NM_001290022 NM_001290026 NM_001290027 NM_001290028 NM_199228 NM_199356 NM_001173505 NM_009379 NM_001289894 NM_001289896 RefSeq (protein) NP_000451 NP_001171068 NP_001171069 NP_001276926 NP_001276927 NP_001276932 NP_001276951 NP_001276955 NP_001276956 NP_001276957 NP_001166976 NP_001276823 NP_001276825 NP_033405 Location (UCSC) Chr 3: 184.37 – 184.38 Mb Chr 16: 20.54 – 20.55 Mb PubMed search [3] [4]
Wikidata
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Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene.

Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets.^[5]

Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene.^[6]