Thrombopoietin receptor

MPL
Identifiers
Aliases	MPL, C-CD110, MPLV, THCYT2, TPOR, MPL proto-oncogene, thrombopoietin receptor, THPOR
External IDs	OMIM: 159530; MGI: 97076; HomoloGene: 7845; GeneCards: MPL; OMA:MPL - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	43,354,466 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	118,314,710 bp
RNA expression pattern
	Top expressed in
	testicle; ; mononuclear cell; ; monocyte; ; right frontal lobe; ; bone marrow cells; ; bronchial epithelial cell; ; sural nerve; ; left ovary; ; Brodmann area 9; ; prefrontal cortex;
	Top expressed in
	blood; ; gastrula; ; vasculature of trunk; ; tibiofemoral joint; ; embryo; ; dorsal aorta; ; morula; ; yolk sac; ; embryo; ; spleen;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; protein binding; transmembrane signaling receptor activity; thrombopoietin receptor activity;
Cellular component	integral component of membrane; cell surface; Golgi apparatus; integral component of plasma membrane; membrane; plasma membrane; neuron projection; neuronal cell body;
Biological process	cell surface receptor signaling pathway; cell population proliferation; cytokine-mediated signaling pathway; thrombopoietin-mediated signaling pathway; neutrophil homeostasis; monocyte homeostasis; positive regulation of lymphocyte proliferation; platelet aggregation; cellular response to hypoxia; positive regulation of platelet formation; eosinophil homeostasis; basophil homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	4352
	17480
	ENSG00000117400
	ENSMUSG00000006389
	P40238
	Q08351
	NM_005373
	NM_001122949; NM_001285496; NM_001285497; NM_010823
	NP_005364
	NP_001116421; NP_001272425; NP_001272426; NP_034953
	Wikidata
View/Edit Human	View/Edit Mouse

The thrombopoietin receptor also known as the myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110) is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117400 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006389 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MPL myeloproliferative leukemia virus oncogene".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117400 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006389 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MPL myeloproliferative leukemia virus oncogene".

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