Thrombospondin 1

THBS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTHBS1, THBS, THBS-1, TSP, TSP-1, TSP1, thrombospondin 1
External IDsOMIM: 188060; MGI: 98737; HomoloGene: 31142; GeneCards: THBS1; OMA:THBS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003246

NM_011580
NM_001313914

RefSeq (protein)

NP_003237

n/a

Location (UCSC)Chr 15: 39.58 – 39.6 MbChr 2: 117.94 – 117.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene.[5][6]

Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, collagens types V and VII and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.[7][8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137801Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040152Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wolf FW, Eddy RL, Shows TB, Dixit VM (Apr 1990). "Structure and chromosomal localization of the human thrombospondin gene" (PDF). Genomics. 6 (4): 685–91. doi:10.1016/0888-7543(90)90505-O. hdl:2027.42/28657. PMID 2341158.
  6. ^ Jaffe E, Bornstein P, Disteche CM (May 1990). "Mapping of the thrombospondin gene to human chromosome 15 and mouse chromosome 2 by in situ hybridization". Genomics. 7 (1): 123–6. doi:10.1016/0888-7543(90)90528-3. PMID 2335352.
  7. ^ "Entrez Gene: THBS1 thrombospondin 1".
  8. ^ Atanasova VS, Russell RJ, Webster TG, Cao Q, Agarwal P, Lim YZ, Krishnan S, Fuentes I, Guttmann-Gruber C, McGrath JA, Salas-Alanis JC, Fertala A, South AP (July 2019). "Thrombospondin-1 Is a Major Activator of TGF-β Signaling in Recessive Dystrophic Epidermolysis Bullosa Fibroblasts". The Journal of Investigative Dermatology. 139 (7): 1497–1505.e5. doi:10.1016/j.jid.2019.01.011. PMID 30684555.