Thromboxane-A synthase

TBXAS1
Identifiers
Aliases	TBXAS1, BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS, thromboxane A synthase 1
External IDs	OMIM: 274180; MGI: 98497; HomoloGene: 130979; GeneCards: TBXAS1; OMA:TBXAS1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	140,020,325 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	39,061,519 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; spleen; ; right lung; ; gallbladder; ; upper lobe of left lung; ; C1 segment; ; rectum; ; minor salivary glands;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; gastrula; ; blood; ; right kidney; ; mesenteric lymph nodes; ; spleen; ; ascending aorta; ; aortic valve; ; CA3 field;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; isomerase activity; metal ion binding; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; 12-hydroxyheptadecatrienoic acid synthase activity; thromboxane-A synthase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	prostaglandin metabolic process; lipid metabolism; icosanoid metabolic process; cyclooxygenase pathway; fatty acid metabolic process; fatty acid biosynthetic process; prostaglandin biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	6916
	21391
	ENSG00000059377
	ENSMUSG00000029925
	P24557
	P36423
NM_001314028; NM_001061; NM_001130966; NM_001166253; NM_001166254;
	NM_030984; NM_001366537; NM_001366538
	NM_011539
NP_001052; NP_001124438; NP_001159725; NP_001159726; NP_001300957;
	NP_112246; NP_001353466; NP_001353467
	NP_035669
	Wikidata
View/Edit Human	View/Edit Mouse

Thromboxane A synthase 1 (EC 5.3.99.5, platelet, cytochrome P450, family 5, subfamily A), also known as TBXAS1, is a cytochrome P450 enzyme that, in humans, is encoded by the TBXAS1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000059377 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029925 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)".
^ Yokoyama C, Miyata A, Ihara H, Ullrich V, Tanabe T (August 1991). "Molecular cloning of human platelet thromboxane A synthase". Biochemical and Biophysical Research Communications. 178 (3): 1479–1484. doi:10.1016/0006-291X(91)91060-P. PMID 1714723.
^ Baek SJ, Lee KD, Shen RF (September 1996). "Genomic structure and polymorphism of the human thromboxane synthase-encoding gene". Gene. 173 (2): 251–256. doi:10.1016/0378-1119(95)00881-0. PMID 8964509.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000059377 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029925 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)".

[pmid1714723-6] Yokoyama C, Miyata A, Ihara H, Ullrich V, Tanabe T (August 1991). "Molecular cloning of human platelet thromboxane A synthase". Biochemical and Biophysical Research Communications. 178 (3): 1479–1484. doi:10.1016/0006-291X(91)91060-P. PMID 1714723.

[pmid8964509-7] Baek SJ, Lee KD, Shen RF (September 1996). "Genomic structure and polymorphism of the human thromboxane synthase-encoding gene". Gene. 173 (2): 251–256. doi:10.1016/0378-1119(95)00881-0. PMID 8964509.

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