 | This article may be too technical for most readers to understand. (November 2017) |
| Thymidine phosphorylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Thymidine phosphorylase protein structure | |||||||||
| Identifiers | |||||||||
| EC no. | 2.4.2.4 | ||||||||
| CAS no. | 9030-23-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thymidine phosphorylase (EC 2.4.2.4) is an enzyme that is encoded by the TYMP gene and catalyzes the reaction:
- thymidine + phosphate thymine + 2-deoxy-alpha-D-ribose 1-phosphate
Thymidine phosphorylase is involved in purine metabolism, pyrimidine metabolism, and other metabolic pathways. Variations in thymidine phosphorylase and the TYMP gene that encode it are associated with mitochondrial neurogastrointestinal encephalopathy (MNGIE) syndrome and bladder cancer.