Tiletamine

Tiletamine
(S)-tiletamine
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		IV, IM, SC, Other
ATC code
  • none
Legal status
Legal status
Pharmacokinetic data
MetabolismLiver
ExcretionKidneys
Identifiers
  • 2-Ethylamino-2-(2-thienyl)cyclohexanone
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.034.559 Edit this at Wikidata
Chemical and physical data
FormulaC12H17NOS
Molar mass223.33 g·mol−1
3D model (JSmol)
  • O=C2C(c1sccc1)(NCC)CCCC2
  • InChI=1S/C12H17NOS/c1-2-13-12(11-7-5-9-15-11)8-4-3-6-10(12)14/h5,7,9,13H,2-4,6,8H2,1H3 checkY
  • Key:QAXBVGVYDCAVLV-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist.[1] It is related chemically to ketamine.[2] Tiletamine hydrochloride exists as odorless white crystals.

It is used in veterinary medicine in the combination product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs.[3][4][5] It is sometimes used in combination with xylazine (Rompun) to chemically immobilize large mammals such as polar bears[6] and wood bison.[7] Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.[3]

  1. ^ Klockgether T, Turski L, Schwarz M, Sontag KH, Lehmann J (October 1988). "Paradoxical convulsant action of a novel non-competitive N-methyl-D-aspartate (NMDA) antagonist, tiletamine". Brain Research. 461 (2): 343–348. doi:10.1016/0006-8993(88)90265-X. PMID 2846121. S2CID 41671395.
  2. ^ CID 26533 from PubChem
  3. ^ a b "Tiletamine". Drugs.com. Retrieved 5 January 2012.
  4. ^ Lin HC, Thurmon JC, Benson GJ, Tranquilli WJ (December 1993). "Telazol--a review of its pharmacology and use in veterinary medicine". Journal of Veterinary Pharmacology and Therapeutics. 16 (4): 383–418. doi:10.1111/j.1365-2885.1993.tb00206.x. PMID 8126757.
  5. ^ "Tiletamine". Toxnet. U.S. National Library of Medicine. 21 January 2009.
  6. ^ Cattet MR, Caulkett NA, Lunn NJ (July 2003). "Anesthesia of polar bears using xylazine-zolazepam-tiletamine or zolazepam-tiletamine". Journal of Wildlife Diseases. 39 (3): 655–664. doi:10.7589/0090-3558-39.3.655. PMID 14567228.
  7. ^ Caulkett NA, Cattet MR, Cantwell S, Cool N, Olsen W (January 2000). "Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations". The Canadian Veterinary Journal. 41 (1): 49–53. doi:10.4141/cjas61-007. PMC 1476335. PMID 10642872.