Tilsley may refer to:
- Colin Tilsley (1935–1981), the founder of Gospel Literature Outreach
- Frank Tilsley (1904–1957), British novelist, broadcaster, and television dramatist from Manchester
- Gwilym Tilsley (1911–1997), bardic name of "Tilsli", Welsh poet, Archdruid of the National Eisteddfod of Wales
- Paul Tilsley, deputy leader of Birmingham City Council
- Reg Tilsley (1926–1987), British composer