Tiludronic acid

Tiludronic acid
Clinical data
Trade names	Skelid
AHFS/Drugs.com	International Drug Names
ATC code	M05BA05 (WHO) ;
Legal status
Legal status	CA: ℞-only;
Identifiers
	IUPAC name {[(4-Chlorophenyl)thio]methylene}bis(phosphonic acid);
CAS Number	89987-06-4 ;
PubChem CID	60937;
IUPHAR/BPS	7604;
DrugBank	DB01133 ;
ChemSpider	54905 ;
UNII	6PNS59HP4Y;
KEGG	D08599 ;
ChEMBL	ChEMBL1350 ;
CompTox Dashboard (EPA)	DTXSID10237966 ;
ECHA InfoCard	100.121.105
Chemical and physical data
Formula	C7H9ClO6P2S
Molar mass	318.60 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1cc(ccc1SC(P(=O)(O)O)P(=O)(O)O)Cl;
	InChI InChI=1S/C7H9ClO6P2S/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14/h1-4,7H,(H2,9,10,11)(H2,12,13,14) ; Key:DKJJVAGXPKPDRL-UHFFFAOYSA-N ;
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Tiludronic acid (INN; also known as tiludronate) is a bisphosphonate used for treatment of Paget's disease of bone (osteitis deformans) in human being medicine. It has the tradename Skelid. In veterinary medicine, tiludronic acid is used to treat navicular disease and bone spavin in horses. Its tradenames are Tildren and Equidronate. It is approved for treatment of navicular disease and distal, tarsal osteoarthritis in Europe,^[1] and was approved for treatment of navicular disease in the United States in 2014.

^ Kamm L, McIlwraith W, Kawcak C (2008). "A review of the Efficacy of Tiludronate in the Horse". Journal or Equine Veterinary Science. 28 (4): 209–214. doi:10.1016/j.jevs.2008.02.007.

[1] Kamm L, McIlwraith W, Kawcak C (2008). "A review of the Efficacy of Tiludronate in the Horse". Journal or Equine Veterinary Science. 28 (4): 209–214. doi:10.1016/j.jevs.2008.02.007.

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