Tolterodine

Tolterodine
Clinical data
Trade namesDetrol, Detrusitol, others
Other namesPNU-200583E
AHFS/Drugs.comMonograph
MedlinePlusa699026
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability77%
Protein bindingApproximately 96.3%
Elimination half-life1.9–3.7 hours
Identifiers
  • (S)-2-[3-(Diisopropylamino)-1-phenylpropyl]-4-methylphenol
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.232.068 Edit this at Wikidata
Chemical and physical data
FormulaC22H31NO
Molar mass325.496 g·mol−1
3D model (JSmol)
  • Cc1ccc(c(c1)[C@H](CCN(C(C)C)C(C)C)c2ccccc2)O
  • InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1 checkY
  • Key:OOGJQPCLVADCPB-HXUWFJFHSA-N checkY
  (verify)

Tolterodine, sold under the brand name Detrol among others, is a medication used to treat frequent urination, urinary incontinence, or urinary urgency.[5] Effects are seen within an hour.[6] It is taken by mouth.[6][7]

Common side effects include headache, dry mouth, constipation, and dizziness.[6] Serious side effects may include angioedema, urinary retention, and QT prolongation.[6] Use in pregnancy and breastfeeding are of unclear safety.[5][8] It works by blocking muscarinic receptors in the bladder thus decreasing bladder contractions.[6]

Tolterodine was approved for medical use in 1998.[6] It is available as a generic medication.[5] In 2020, it was the 271st most commonly prescribed medication in the United States, with more than 1 million prescriptions.[9][10]

  1. ^ "Detrusitol 1mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 9 March 2021. Retrieved 12 May 2022.
  2. ^ "Detrol- tolterodine tartrate tablet, film coated". DailyMed. 29 September 2021. Retrieved 12 May 2022.
  3. ^ "Detrol LA- tolterodine tartrate capsule, extended release". DailyMed. 12 October 2020. Retrieved 12 May 2022.
  4. ^ "List of nationally authorised medicinal products" (PDF). ema.europa.eu. 5 May 2022. Retrieved 9 November 2023.
  5. ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 762. ISBN 9780857113382.
  6. ^ a b c d e f "Tolterodine Tartrate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  7. ^ Narain S, Parmar M (January 2021). "Tolterodine". StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 32491781.
  8. ^ "Tolterodine Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
  9. ^ "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
  10. ^ "Tolterodine - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.