Toni Choueiri

Toni Choueiri
Toni Choueiri
Born	Beirut, Lebanon
Academic background
Education	MD, Saint Joseph University Residency/Fellowship, Cleveland Clinic
Academic work
Institutions	Dana–Farber Cancer Institute

Toni K. Choueiri is a Lebanese American medical oncologist and researcher. He is the Jerome and Nancy Kohlberg Professor of Medicine at Harvard Medical School and Director of the Lank Center for Genitourinary Oncology at the Dana–Farber Cancer Institute. His work has led to the establishment of several novel drugs (cabozantinib, avelumab, pazopanib and others including combinations) and prognostic factors in advanced renal cell carcinoma (RCC). Choueiri also co-established the International metastatic database Consortium with Daniel Heng. His biomarker work has shed light on complex immunogenomics mechanisms contributing to response and resistance to targeted therapy and immunotherapy.^[1]^[2]

^ Motzer, R. J.; Robbins, P. B.; Powles, T.; Albiges, L.; Haanen, J. B.; Larkin, J.; Mu, X. J.; Ching, K. A.; Uemura, M.; Pal, S. K.; Alekseev, B.; Gravis, G.; Campbell, M. T.; Penkov, K.; Lee, J. L.; Hariharan, S.; Wang, X.; Zhang, W.; Wang, J.; Chudnovsky, A.; Di Pietro, A.; Donahue, A. C.; Choueiri, T. K. (November 2020). "Avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma: biomarker analysis of the phase 3 JAVELIN Renal 101 trial". Nature Medicine. 26 (11): 1733–1741. doi:10.1038/s41591-020-1044-8. PMC 8493486. PMID 32895571.
^ Miao, D.; Margolis, C. A.; Gao, W.; Voss, M. H.; Li, W.; Martini, D. J.; Norton, C.; Bossé, D.; Wankowicz, S. M.; Cullen, D.; Horak, C.; Wind-Rotolo, M.; Tracy, A.; Giannakis, M.; Hodi, F. S.; Drake, C. G.; Ball, M. W.; Allaf, M. E.; Snyder, A.; Hellmann, M. D.; Ho, T.; Motzer, R. J.; Signoretti, S.; Kaelin Jr, W. G.; Choueiri, T. K.; Van Allen, E. M. (February 16, 2018). "Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma". Science. 359 (6377): 801–806. Bibcode:2018Sci...359..801M. doi:10.1126/science.aan5951. PMC 6035749. PMID 29301960.

[1] Motzer, R. J.; Robbins, P. B.; Powles, T.; Albiges, L.; Haanen, J. B.; Larkin, J.; Mu, X. J.; Ching, K. A.; Uemura, M.; Pal, S. K.; Alekseev, B.; Gravis, G.; Campbell, M. T.; Penkov, K.; Lee, J. L.; Hariharan, S.; Wang, X.; Zhang, W.; Wang, J.; Chudnovsky, A.; Di Pietro, A.; Donahue, A. C.; Choueiri, T. K. (November 2020). "Avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma: biomarker analysis of the phase 3 JAVELIN Renal 101 trial". Nature Medicine. 26 (11): 1733–1741. doi:10.1038/s41591-020-1044-8. PMC 8493486. PMID 32895571.

[2] Miao, D.; Margolis, C. A.; Gao, W.; Voss, M. H.; Li, W.; Martini, D. J.; Norton, C.; Bossé, D.; Wankowicz, S. M.; Cullen, D.; Horak, C.; Wind-Rotolo, M.; Tracy, A.; Giannakis, M.; Hodi, F. S.; Drake, C. G.; Ball, M. W.; Allaf, M. E.; Snyder, A.; Hellmann, M. D.; Ho, T.; Motzer, R. J.; Signoretti, S.; Kaelin Jr, W. G.; Choueiri, T. K.; Van Allen, E. M. (February 16, 2018). "Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma". Science. 359 (6377): 801–806. Bibcode:2018Sci...359..801M. doi:10.1126/science.aan5951. PMC 6035749. PMID 29301960.

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