Transcription factor II A

general transcription factor IIA, 2, 12kDa
general transcription factor IIA, 2, 12kDa
Identifiers
Symbol	GTF2A2
NCBI gene	2958
HGNC	4647
OMIM	600519
RefSeq	NM_004492
UniProt	P52657
Other data
Locus	Chr. 15 q21.3
Structures
Search for
Structures	Swiss-model
Domains	InterPro

general transcription factor IIA, 1, 19/37kDa
general transcription factor IIA, 1, 19/37kDa
Identifiers
Symbol	GTF2A1
NCBI gene	2957
HGNC	4646
OMIM	600520
RefSeq	NM_201595
UniProt	P52655
Other data
Locus	Chr. 14 q31
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Transcription factor TF_IIA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA.^[1] TF_IIA is one of several general (basal) transcription factors (GTFs) that are required for all transcription events that use RNA polymerase II. Other GTFs include TF_IID, a complex composed of the TATA binding protein TBP and TBP-associated factors (TAFs), as well as the factors TF_IIB, TF_IIE, TF_IIF, and TF_IIH. Together, these factors are responsible for promoter recognition and the formation of a transcription preinitiation complex (PIC) capable of initiating RNA synthesis from a DNA template.

^ Høiby T, Zhou H, Mitsiou DJ, Stunnenberg HG (2007). "A facelift for the general transcription factor TFIIA". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1769 (7–8): 429–36. doi:10.1016/j.bbaexp.2007.04.008. hdl:2066/34866. PMID 17560669.