Property of genes where transcription from DNA to RNA occurs in "bursts"
Transcriptional bursting , also known as transcriptional pulsing , is a fundamental property of genes in which transcription from DNA to RNA can occur in "bursts" or "pulses", which has been observed in diverse organisms, from bacteria to mammals.[ 1] [ 2] [ 3] [ 4] [ 5]
^ Golding, I; Paulsson, J; Zawilski, SM; Cox, EC (2005). "Real-time kinetics of gene activity in individual bacteria" . Cell . 123 (6): 1025–36. doi :10.1016/j.cell.2005.09.031 PMID 16360033 . ^ Chubb, JR; Trcek, T; Shenoy, SM; Singer, RH (2006). "Transcriptional pulsing of a developmental gene" . Current Biology . 16 (10): 1018–25. doi :10.1016/j.cub.2006.03.092 . PMC 4764056 PMID 16713960 . ^ Raj, A; Peskin, CS; Tranchina, D; Vargas, DY; Tyagi, S (2006). "Stochastic mRNA Synthesis in Mammalian Cells" . PLOS Biology . 4 (10): e309. doi :10.1371/journal.pbio.0040309 PMC 1563489 PMID 17048983 . ^ Bahar Halpern, K; Tanami, S; Landen, S; Chapal, M; Szlak, L; Hutzler, A; Nizhberg, A; Itzkovitz, S (2015). "Bursty gene expression in the intact mammalian liver" . Molecular Cell . 58 (1): 147–56. doi :10.1016/j.molcel.2015.01.027 . PMC 4500162 PMID 25728770 . ^ Suter, DM; Molina, N; Gatfield, D; Schneider, K; Schibler, U; Naef, F (2011). "Mammalian genes are transcribed with widely different bursting kinetics". Science . 332 (6028): 472–4. Bibcode :2011Sci...332..472S . doi :10.1126/science.1198817 . PMID 21415320 . S2CID 20816960 .