Transforming protein RhoA

RHOA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5BWM, 1A2B, 1CC0, 1CXZ, 1DPF, 1FTN, 1KMQ, 1LB1, 1OW3, 1S1C, 1TX4, 1X86, 1XCG, 2RGN, 3KZ1, 3LW8, 3LWN, 3LXR, 3MSX, 3T06, 4D0N, 4XH9, 4XSG, 4XSH, 4XOI, 5A0F, 5FR2, 5FR1, 5JCP, 5C2K, 5C4M, 5HPY
Identifiers
Aliases	RHOA, ARH12, ARHA, RHO12, RHOH12, ras homolog family member A, EDFAOB
External IDs	OMIM: 165390; MGI: 1096342; HomoloGene: 68986; GeneCards: RHOA; OMA:RHOA - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,359,139 bp[1] End 49,412,998 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F2 Start 108,183,328 bp[2] End 108,215,133 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte skin of hip popliteal artery tibial arteries synovial joint thymus right lung skin of arm trabecular bone left coronary artery Top expressed in seminal vesicula ascending aorta aortic valve granulocyte left lung lobe thymus dermis umbilical cord decidua stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding myosin binding GTP binding protein binding GTPase activity GDP binding protein kinase binding protein domain specific binding Rho GDP-dissociation inhibitor binding Cellular component cytoplasm vesicle cytosol endosome cell projection endoplasmic reticulum membrane membrane focal adhesion extrinsic component of cytoplasmic side of plasma membrane plasma membrane cell junction cell cortex midbody cleavage furrow cytoskeleton apical junction complex extracellular exosome cell periphery lamellipodium secretory granule membrane ficolin-1-rich granule membrane nucleus axon cell division site ruffle membrane dendritic spine intracellular membrane-bounded organelle postsynapse glutamatergic synapse intracellular anatomical structure Biological process actin cytoskeleton reorganization ossification involved in bone maturation apolipoprotein A-I-mediated signaling pathway regulation of cell migration negative chemotaxis regulation of actin cytoskeleton organization cleavage furrow formation substantia nigra development ephrin receptor signaling pathway endothelial tube lumen extension Roundabout signaling pathway positive regulation of axonogenesis stress fiber assembly positive regulation of lipase activity regulation of osteoblast proliferation cell division positive regulation of cytokinesis platelet activation negative regulation of cell migration involved in sprouting angiogenesis positive regulation of protein serine/threonine kinase activity mitotic cleavage furrow formation mitotic spindle assembly negative regulation of axonogenesis vascular endothelial growth factor receptor signaling pathway skeletal muscle satellite cell migration trabecula morphogenesis positive regulation of neuron differentiation Rho protein signal transduction positive regulation of I-kappaB kinase/NF-kappaB signaling cell cycle viral process regulation of small GTPase mediated signal transduction transforming growth factor beta receptor signaling pathway cell migration apical junction assembly wound healing, spreading of cells endothelial cell migration positive regulation of stress fiber assembly actin cytoskeleton organization phosphatidylinositol-mediated signaling small GTPase mediated signal transduction regulation of cell motility Wnt signaling pathway, planar cell polarity pathway protein deubiquitination neutrophil degranulation cell morphogenesis response to hypoxia angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure alpha-beta T cell lineage commitment regulation of systemic arterial blood pressure by endothelin regulation of transcription by RNA polymerase II cytoskeleton organization actin filament organization cell adhesion cell-matrix adhesion G protein-coupled receptor signaling pathway skeletal muscle tissue development regulation of actin polymerization or depolymerization regulation of cell shape response to mechanical stimulus response to glucose negative regulation of cell-substrate adhesion regulation of neuron projection development negative regulation of neuron projection development cerebral cortex cell migration forebrain radial glial cell differentiation cell differentiation positive regulation of cell growth positive regulation of cell migration androgen receptor signaling pathway positive regulation of actin filament polymerization establishment or maintenance of actin cytoskeleton polarity stress-activated protein kinase signaling cascade negative regulation of intracellular steroid hormone receptor signaling pathway cell junction assembly odontogenesis negative regulation of I-kappaB kinase/NF-kappaB signaling response to amino acid positive regulation of cysteine-type endopeptidase activity involved in apoptotic process beta selection negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process establishment of epithelial cell apical/basal polarity response to ethanol negative regulation of neuron differentiation positive regulation of translation positive regulation of cell adhesion negative regulation of cell size positive regulation of vasoconstriction positive regulation of smooth muscle contraction GTP metabolic process positive regulation of alpha-beta T cell differentiation neuron projection morphogenesis regulation of dendrite development actin filament bundle assembly response to glucocorticoid regulation of focal adhesion assembly regulation of calcium ion transport negative regulation of cell death regulation of microtubule cytoskeleton organization cellular response to lipopolysaccharide cellular response to cytokine stimulus positive regulation of podosome assembly negative regulation of oxidative phosphorylation positive regulation of NIK/NF-kappaB signaling negative regulation of reactive oxygen species biosynthetic process positive regulation of vascular associated smooth muscle contraction positive regulation of leukocyte adhesion to vascular endothelial cell regulation of modification of synaptic structure regulation of modification of postsynaptic actin cytoskeleton cellular response to chemokine regulation of neural precursor cell proliferation positive regulation of T cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 387 11848 Ensembl ENSG00000067560 ENSMUSG00000007815 UniProt P61586 Q9QUI0 RefSeq (mRNA) NM_001313941 NM_001313943 NM_001313944 NM_001313945 NM_001313946 NM_001313947 NM_001664 NM_016802 NM_001313961 NM_001313962 RefSeq (protein) NP_001300870 NP_001300872 NP_001300873 NP_001300874 NP_001300875 NP_001300876 NP_001655 NP_001300870.1 NP_001655.1 NP_001300890 NP_001300891 NP_058082 Location (UCSC) Chr 3: 49.36 – 49.41 Mb Chr 9: 108.18 – 108.22 Mb PubMed search [3] [4]
Wikidata
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Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the RHOA gene.^[5] While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. It acts upon several effectors. Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in Drosophila) are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billion years. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evolution. RhoA specifically is regarded as a prominent regulatory factor in other functions such as the regulation of cytoskeletal dynamics, transcription, cell cycle progression and cell transformation.