Translational glycobiology

Translational glycobiology or applied glycobiology is the branch of glycobiology and glycochemistry that focuses on developing new pharmaceuticals through glycomics and glycoengineering.[1] Although research in this field presents many difficulties, translational glycobiology presents applications with therapeutic glycoconjugates, with treating various bone diseases, and developing therapeutic cancer vaccines and other targeted therapies.[2][3] Some mechanisms of action include using the glycan for drug targeting, engineering protein glycosylation for better efficacy, and glycans as drugs themselves.

  1. ^ Sackstein R (June 2016). "Fulfilling Koch's postulates in glycoscience: HCELL, GPS and translational glycobiology". Glycobiology. 26 (6): 560–570. doi:10.1093/glycob/cww026. PMC 4847618. PMID 26933169.
  2. ^ Slovin SF, Keding SJ, Ragupathi G (August 2005). "Carbohydrate vaccines as immunotherapy for cancer". Immunology and Cell Biology. 83 (4): 418–428. doi:10.1111/j.1440-1711.2005.01350.x. PMID 16033538. S2CID 40251150.
  3. ^ Umaña P, Jean-Mairet J, Moudry R, Amstutz H, Bailey JE (February 1999). "Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity". Nature Biotechnology. 17 (2): 176–180. doi:10.1038/6179. PMID 10052355. S2CID 20078393.