| Treponema denticola | |
|---|---|
Scientific classification 
| |
| Domain: | Bacteria |
| Phylum: | Spirochaetota |
| Class: | Spirochaetia |
| Order: | Spirochaetales |
| Family: | Treponemataceae |
| Genus: | Treponema |
| Species: | T. denticola
|
| Binomial name | |
| Treponema denticola (ex Flügge 1886) Chan et al. 1993[1]
| |
Treponema denticola is a Gram-negative, obligate anaerobic, motile and highly proteolytic spirochete bacterium. It is one of four species of oral spirochetes to be reliably cultured, the others being Treponema pectinovorum, Treponema socranskii and Treponema vincentii[2]. T. denticola dwells in a complex and diverse microbial community within the oral cavity and is highly specialized to survive in this environment. T. denticola is associated with the incidence and severity of human periodontal disease. Treponema denticola is one of three bacteria that form the Red Complex, the other two being Porphyromonas gingivalis and Tannerella forsythia. Together they form the major virulent pathogens that cause chronic periodontitis.[3] Having elevated T. denticola levels in the mouth is considered one of the main etiological agents of periodontitis.[4][5] T. denticola is related to the syphilis-causing obligate human pathogen, Treponema pallidum subsp. pallidum. It has also been isolated from women with bacterial vaginosis.[6]
- ^ Parte AC. "Treponema". LPSN.
- ^ Chan EC, McLaughlin R (February 2000). "Taxonomy and virulence of oral spirochetes". Oral Microbiology and Immunology. 15 (1): 1–9. doi:10.1034/j.1399-302x.2000.150101.x. PMID 11155157.
- ^ Öğrendik M (March 2017). "Periodontal Pathogens in the Etiology of Pancreatic Cancer". Gastrointestinal Tumors. 3 (3–4): 125–127. doi:10.1159/000452708. PMC 5465713. PMID 28611978.
- ^ Marie-Claude Jobin; Mohsen Amin; Richard P. Ellen (2008). "Chapter 8 - The Molecular Biology of the Survival and Virulence of Treponema denticola". In Anthony H. Rogers (ed.). Molecular Oral Microbiology. Caister Academic Press. p. 177. ISBN 978-1-904455-24-0.
- ^ Simonson LG, Goodman CH, Bial JJ, Morton HE (April 1988). "Quantitative relationship of Treponema denticola to severity of periodontal disease". Infection and Immunity. 56 (4): 726–8. doi:10.1128/IAI.56.4.726-728.1988. PMC 259361. PMID 3346072.
- ^ Africa CW, Nel J, Stemmet M (July 2014). "Anaerobes and bacterial vaginosis in pregnancy: virulence factors contributing to vaginal colonisation". International Journal of Environmental Research and Public Health. 11 (7): 6979–7000. doi:10.3390/ijerph110706979. PMC 4113856. PMID 25014248.