Triazolam

"Halcion" redirects here. For similar terms, see Halcyon (disambiguation).

Triazolam
Clinical data
Trade namesHalcion, others
AHFS/Drugs.comMonograph
MedlinePlusa684004
License data
Pregnancy
category
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability44% (oral route), 53% (sublingual)
MetabolismLiver
Onset of action15–30 minutes[4]
Elimination half-life1.5–5.5 hours
ExcretionKidney
Identifiers
  • 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.044.811 Edit this at Wikidata
Chemical and physical data
FormulaC17H12Cl2N4
Molar mass343.21 g·mol−1
3D model (JSmol)
  • Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2
  • InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3 checkY
  • Key:JOFWLTCLBGQGBO-UHFFFAOYSA-N checkY
  (verify)

Triazolam, sold under the brand name Halcion among others, is a central nervous system (CNS) depressant tranquilizer of the triazolobenzodiazepine (TBZD) class, which are benzodiazepine (BZD) derivatives.[5] It possesses pharmacological properties similar to those of other benzodiazepines, but it is generally only used as a sedative to treat severe insomnia.[6][unreliable medical source?] In addition to the hypnotic properties, triazolam's amnesic, anxiolytic, sedative, anticonvulsant, and muscle relaxant properties are pronounced as well.[7]

Triazolam was initially patented in 1970 and went on sale in the United States in 1982.[8] In 2017, it was the 289th most commonly prescribed medication in the United States, with more than one million prescriptions.[9]

  1. ^ "Triazolam (Halcion) Use During Pregnancy". Drugs.com. 18 September 2020. Retrieved 24 October 2020.
  2. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  3. ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
  4. ^ "What Is Triazolam Used For?". www.icliniq.com. 1 November 2022. Retrieved 30 January 2023.
  5. ^ "Benzodiazepine Names". non-benzodiazepines. Archived from the original on 8 December 2008. Retrieved 29 December 2008.
  6. ^ Wishart, David (2006). "Triazolam". DrugBank. Retrieved 23 March 2006.
  7. ^ Mandrioli R, Mercolini L, Raggi MA (October 2008). "Benzodiazepine metabolism: an analytical perspective". Current Drug Metabolism. 9 (8): 827–844. doi:10.2174/138920008786049258. PMID 18855614.
  8. ^ Shorter E (2005). "B". A Historical Dictionary of Psychiatry. Oxford University Press. ISBN 9780190292010.
  9. ^ "Triazolam - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.