Trifluoperazine

Trifluoperazine
Clinical data
Trade names	Stelazine, Eskazinyl, Eskazine, Jatroneural, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682121
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth, IM
Drug class	Typical antipsychotic
ATC code	N05AB06 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances); UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Metabolism	Liver
Elimination half-life	10–20 hours
Identifiers
	IUPAC name 10-[3-(4-methylpiperazin-1-yl)propyl]-; 2-(trifluoromethyl)-10H-phenothiazine;
CAS Number	117-89-5 ;
PubChem CID	5566;
IUPHAR/BPS	214;
DrugBank	DB00831 ;
ChemSpider	5365 ;
UNII	214IZI85K3;
ChEBI	CHEBI:45951 ;
ChEMBL	ChEMBL422 ;
PDB ligand	TFP (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID1046928 ;
ECHA InfoCard	100.003.837
Chemical and physical data
Formula	C21H24F3N3S
Molar mass	407.50 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4;
	InChI InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3 ; Key:ZEWQUBUPAILYHI-UHFFFAOYSA-N ;
	(verify)

Trifluoperazine, marketed under the brand name Stelazine among others, is a typical antipsychotic primarily used to treat schizophrenia.^[3] It may also be used short term in those with generalized anxiety disorder but is less preferred to benzodiazepines.^[3] It is of the phenothiazine chemical class. It was approved for medical use in the United States in 1959.^[4]

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ ^a ^b "Trifluoperazine Hydrochloride". The American Society of Health-System Pharmacists. Retrieved 8 January 2017.
^ Howland RH (January 2016). "Trifluoperazine: A Sprightly Old Drug". Journal of Psychosocial Nursing and Mental Health Services. 54 (1): 20–2. doi:10.3928/02793695-20151223-01. PMID 26760133.