Tropicamide

Tropicamide
Clinical data
Trade namesMydriacyl, others
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • C
Routes of
administration		Topical eye drops
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding45%
Identifiers
  • (RS)-N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.014.673 Edit this at Wikidata
Chemical and physical data
FormulaC17H20N2O2
Molar mass284.359 g·mol−1
3D model (JSmol)
  • CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1
  • InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
  • Key:BGDKAVGWHJFAGW-UHFFFAOYSA-N
 ☒NcheckY (what is this?)  (verify)

Tropicamide, sold under the brand name Mydriacyl among others, is a medication used to dilate the pupil and help with examination of the eye.[3] Specifically it is used to help examine the back of the eye.[4] It is applied as eye drops.[3] Effects occur within 40 minutes and last for up to a day.[3]

Common side effects include blurry vision, increased intraocular pressure, and sensitivity to light.[3] Another rare but severe side effect is psychosis, particularly in children.[3] It is unclear if use during pregnancy is safe for the fetus.[5] Tropicamide is in the antimuscarinic part of the anticholinergic family of medications.[3] It works by making the muscles within the eye unable to respond to nerve signals.[3]

Tropicamide was approved for medical use in the United States in 1960.[3] It is on the World Health Organization's List of Essential Medicines.[6]

  1. ^ "Summary for ARTG Entry: 25356 Mydriacyl tropicamide 0.5% eye drops bottle". Therapeutic Goods Administration. Archived from the original on 5 June 2023. Retrieved 5 June 2023.
  2. ^ "Mydriacyl 1% eye drops, solution - Summary of Product Characteristics (SmPC)". Electronic Medicines Compendium. 12 February 2020. Archived from the original on 27 June 2022. Retrieved 29 July 2020.
  3. ^ a b c d e f g h "Tropicamide". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 December 2016. Retrieved 8 December 2016.
  4. ^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 314. hdl:10665/44053. ISBN 9789241547659.
  5. ^ "Tropicamide ophthalmic Use During Pregnancy". Drugs.com. Archived from the original on 28 December 2016. Retrieved 28 December 2016.
  6. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.