Troponin T

"TnT" redirects here. For other uses, see TNT (disambiguation).
Troponin T
Troponin
Test ofTroponin
Cardiac sarcomere structure featuring troponin T

Troponin T (shortened TnT[1] or TropT) is a part of the troponin complex, which are proteins integral to the contraction of skeletal and heart muscles. They are expressed in skeletal and cardiac myocytes. Troponin T binds to tropomyosin and helps position it on actin,[2] and together with the rest of the troponin complex, modulates contraction of striated muscle.[3] The cardiac subtype of troponin T is especially useful in the laboratory diagnosis of heart attack because it is released into the blood-stream when damage to heart muscle occurs.[4] It was discovered by the German physician Hugo A. Katus at the University of Heidelberg, who also developed the troponin T assay.

  1. ^ Jin, Jian-Ping (2016-01-01), Jeon, Kwang W. (ed.), "Chapter One - Evolution, Regulation, and Function of N-terminal Variable Region of Troponin T: Modulation of Muscle Contractility and Beyond", International Review of Cell and Molecular Biology, 321, Academic Press: 1–28, doi:10.1016/bs.ircmb.2015.09.002, PMID 26811285
  2. ^ marieb, elaine (2004)
  3. ^ black, joyce (2005)
  4. ^ Braunwald's Heart Disease. Elsevier Saunders. 2015. p. 433. ISBN 978-1-4557-5134-1.