Trucker may refer to:
- Truck driver, a person employed as the driver of a truck
- Trucker (band), a rock and alternative country band from Lawrence, KS
- Truckers (2013 TV series), a 2013 drama television series on BBC One
- The first novel in The Nome Trilogy, a series of children's novels by Terry Pratchett
- Truckers (1992 TV series), the UK television series based on the first book from The Nome Trilogy
- Trucker (film), a 2008 US feature film
- Truckers, an upcoming DreamWorks Animation film