Tufa may refer to:
- Tufa, a variety of limestone
- Tufa, Germanic warrior active in 5th century Italy
- North Dock Tufa, petrified tufa formation in Sunderland, England
- Caerwys Tufa, preserved tufa formation in Clwyd, Wales
- Mono Lake Tufa State Natural Reserve, natural reserve in California, United States
- Tufa River, a tributary of the Prahova River in Romania
- Tufa, the founding family of Southern Liang, a state during the Chinese Jin Dynasty
- Tufa Wugu (died 399), founding prince of Southern Liang
- Tufa Lilugu (died 402), second ruler of Southern Liang
- Tufa Rutan (365–415), last ruling prince of Southern Liang
- Princess Tufa (died 423), daughter of Tufa Rutan
- Tufa (Amharic: ቱፋ), a male given name of Ethiopian origin
- Tufa, a summer settlement in Çaykara district of Trabzon province, Turkey.
- Tufa, a fictional clan of fairies in Alex Bledsoe's fantasy novel, The Hum and the Shiver