Tweedie is a surname of Scottish origin. The name is a habitational name from Tweedie, located in the parish of Stonehouse, south of Glasgow. The origin and meaning of the name is unknown.[1][2] Notable people with the surname include:
- Alexander Tweedie (1794–1884), Scottish physician and writer
- Andrew Tweedie (born 1975), South African cricketer
- Charles Tweedie (1868-1925), Scottish mathematician
- Dave Tweedie (born 1968), American composer, multi-instrumentalist and record producer
- David Tweedie (accountant) (born 1944), Scottish accountant
- David Tweedie (mathematician) (1865-1934), Scottish mathematician
- David J. Tweedie (1870-1926), Scottish mathematician
- Ethel Brilliana Tweedie (1862–1940), British author and feminist
- Frederick Tweedie (1877–after 1925), Canadian politician
- George R. Tweedie (1857–after 1893), English businessman
- Herbert J. Tweedie (1864–1906), English golf course architect
- Hugh Tweedie, English officer in the Royal Navy
- Irina Tweedie (1907–1999), Russian-British Sufi
- Jill Tweedie (1936–1993), British feminist, writer and broadcaster
- Lemuel John Tweedie (1849–1917), Canadian politician and father of Frederick Tweedie
- Mark Tweedie (born 1956), American politician
- Maurice Tweedie, British medical physicist and statistician
- Merylyn Tweedie (born 1953), multi-media artist from New Zealand
- Michael Tweedie (1907–1993), naturalist and archaeologist
- Penny Tweedie (1940–2011), English photojournalist
- Richard Tweedie (1947–2001), Australian statistician
- Rob Tweedie (born 1979), American musician
- Scott Tweedie (born 1988), Australian television and radio presenter
- Stephen Tweedie (born 1969), Scottish software developer
- Thomas Tweedie (1871–1944), Canadian politician and Chief Justice
- William Tweedie (1836-1914), Scottish Major-General and Diplomat
- William King Tweedie (1803–1863), Scottish Presbyterian minister
- William Menzies Tweedie (1826–1878), Scottish portrait painter