U.S. Route 52

U.S. Route 52
US 52 highlighted in red
Route information
Length	2,072 mi[citation needed] (3,335 km)
Existed	1926[1]–present
Major junctions
West end	Highway 39 at the Canada–United States border in Portal, ND
Major intersections	I-35W in Minneapolis, MN I-90 in Rochester, MN I-55 in Shorewood, IL I-80 in Joliet, IL I-65 near Lebanon, IN I-70 in Indianapolis, IN I-75 in Cincinnati, OH I-40 in Winston-Salem, NC I-85 in Lexington, NC I-95 near Florence, SC
East end	Line Street in Charleston, SC
Location
Country	United States
States	North Dakota, Minnesota, Iowa, Illinois, Indiana, Ohio, West Virginia, Kentucky, Virginia, North Carolina, South Carolina
Highway system
United States Numbered Highway System List Special Divided
← US 51 US → US 53 ← ND 50 ND → ND 53 ← SR 51 IN → SR 53 ← SR 51 OH → SR 52 ← US 51 KY → KY 52

U.S. Route 52 (US 52) is a major United States highway in the central United States that extends from the northern to southeastern region of the United States. Contrary to most other even-numbered U.S. Highways, US 52 primarily follows a northwest–southeast route, and is signed north–south or east–west depending on the local orientation of the route. The highway's northwestern terminus is in Portal, North Dakota at the Canada–United States border, where it continues as Saskatchewan Highway 39. Its southeastern terminus is in Charleston, South Carolina, at Number 2 Meeting Street and White Point Garden along the Charleston Harbor.