| U12 minor spliceosomal RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of U12 | |
| Identifiers | |
| Symbol | U12 |
| Rfam | RF00007 |
| Other data | |
| RNA type | Gene; snRNA; splicing |
| Domain(s) | Eukaryota |
| GO | GO:0000371 GO:0045131 GO:0005693 |
| SO | SO:0000399 |
| PDB structures | PDBe |
U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns. Although the U12 sequence is very divergent from that of U2, the two are functionally analogous.[1]
- ^ Tarn WY, Steitz JA (April 1997). "Pre-mRNA splicing: the discovery of a new spliceosome doubles the challenge". Trends in Biochemical Sciences. 22 (4): 132–7. doi:10.1016/S0968-0004(97)01018-9. PMID 9149533.