UCK2

UCK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UDW, 1UEI, 1UEJ, 1UFQ, 1UJ2, 1XRJ
Identifiers
Aliases	UCK2, TSA903, UK, UMPK, uridine-cytidine kinase 2
External IDs	OMIM: 609329; MGI: 1931744; HomoloGene: 40850; GeneCards: UCK2; OMA:UCK2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	165,911,618 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	167,112,889 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; ventricular zone; ; ganglionic eminence; ; stromal cell of endometrium; ; placenta; ; rectum; ; mucosa of esophagus; ; cartilage tissue; ; testicle; ; minor salivary glands;
	Top expressed in
	ectoderm; ; otic placode; ; otic vesicle; ; epiblast; ; hair follicle; ; lacrimal gland; ; epithelium of stomach; ; lumbar spinal ganglion; ; mandibular prominence; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; nucleoside kinase activity; uridine kinase activity; ATP binding; kinase activity;
Cellular component	cytosol; cellular component;
Biological process	pyrimidine nucleoside salvage; CMP salvage; metabolism; UMP salvage; CTP salvage; phosphorylation; pyrimidine nucleobase metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	7371
	80914
	ENSG00000143179
	ENSMUSG00000026558
	Q9BZX2
	Q99PM9
	NM_012474; NM_001363568
	NM_030724
	NP_036606; NP_001350497
	NP_109649
	Wikidata
View/Edit Human	View/Edit Mouse

Uridine-cytidine kinase 2 (UCK2) is an enzyme that in humans is encoded by the UCK2 gene.^[5]

The protein encoded by this gene catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively. This is the first step in the production of the pyrimidine nucleoside triphosphates required for RNA and DNA synthesis. In addition, an allele of this gene may play a role in mediating nonhumoral immunity to Hemophilus influenzae type B.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143179 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026558 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: UCK2 uridine-cytidine kinase 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143179 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026558 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: UCK2 uridine-cytidine kinase 2".

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