UGT1A9

UGT1A9
Identifiers
Aliases	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT 1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I, UGT1A9S, UDP glucuronosyltransferase family 1 member A9
External IDs	OMIM: 606434; MGI: 3580642; HomoloGene: 133281; GeneCards: UGT1A9; OMA:UGT1A9 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,773,300 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,146,726 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; renal cortex; ; human kidney; ; mucosa of transverse colon; ; rectum; ; urinary bladder; ; olfactory zone of nasal mucosa; ; duodenum; ; body of stomach; ; islet of Langerhans;
	Top expressed in
	renal cortex; ; nephron; ; proximal tubule; ; renal medulla; ; human kidney; ; hair; ; renal pelvis; ; metanephros; ; lateral recess; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; enzyme inhibitor activity; retinoic acid binding; hexosyltransferase activity; protein homodimerization activity; glycosyltransferase activity; glucuronosyltransferase activity; protein heterodimerization activity; enzyme binding; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	retinoic acid metabolic process; negative regulation of cellular glucuronidation; cellular glucuronidation; flavonoid glucuronidation; xenobiotic glucuronidation; flavone metabolic process; xenobiotic metabolic process; negative regulation of glucuronosyltransferase activity; negative regulation of fatty acid metabolic process; regulation of lipid metabolic process; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	54600
	394430
	ENSG00000241119
	ENSMUSG00000090165
	O60656
	n/a
	NM_021027
	NM_201641
	NP_066307
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 1-9 is an enzyme that in humans is encoded by the UGT1A9 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000241119 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090165 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wooster R, Sutherland L, Ebner T, Clarke D, Da Cruz e Silva O, Burchell B (September 1991). "Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family". The Biochemical Journal. 278 (Pt 2): 465–469. doi:10.1042/bj2780465. PMC 1151367. PMID 1910331.
^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, et al. (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–269. doi:10.1097/00008571-199708000-00001. PMID 9295054.
^ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, et al. (February 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". The Journal of Biological Chemistry. 267 (5): 3257–3261. doi:10.1016/S0021-9258(19)50724-4. PMID 1339448.
^ "Entrez Gene: UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000241119 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090165 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1910331-5] Wooster R, Sutherland L, Ebner T, Clarke D, Da Cruz e Silva O, Burchell B (September 1991). "Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family". The Biochemical Journal. 278 (Pt 2): 465–469. doi:10.1042/bj2780465. PMC 1151367. PMID 1910331.

[pmid9295054-6] Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, et al. (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–269. doi:10.1097/00008571-199708000-00001. PMID 9295054.

[pmid1339448-7] Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, et al. (February 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". The Journal of Biological Chemistry. 267 (5): 3257–3261. doi:10.1016/S0021-9258(19)50724-4. PMID 1339448.

[entrez-8] "Entrez Gene: UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9".

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