UPF1

UPF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GJK, 2GK6, 2GK7, 2IYK, 2WJV, 2WJY, 2XZO, 2XZP
Identifiers
Aliases	UPF1, HNORF1, RENT1, pNORF1, smg-2, RNA helicase and ATPase, UPF1 RNA helicase and ATPase, UTF
External IDs	OMIM: 601430; MGI: 107995; HomoloGene: 2185; GeneCards: UPF1; OMA:UPF1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,868,230 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,805,928 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; granulocyte; ; skin of leg; ; anterior pituitary; ; right uterine tube; ; right testis; ; right lobe of thyroid gland; ; stromal cell of endometrium;
	Top expressed in
	spermatocyte; ; aortic valve; ; granulocyte; ; lip; ; ascending aorta; ; secondary oocyte; ; ventricular zone; ; yolk sac; ; muscle of thigh; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; DNA binding; telomeric DNA binding; zinc ion binding; chromatin binding; metal ion binding; protein binding; hydrolase activity; ATP binding; helicase activity; RNA binding;
Cellular component	cytosol; P-body; exon-exon junction complex; supraspliceosomal complex; nucleoplasm; chromatin; cytoplasm; nucleus;
Biological process	regulation of translational termination; telomere maintenance via semi-conservative replication; positive regulation of mRNA catabolic process; mRNA export from nucleus; DNA replication; nuclear-transcribed mRNA catabolic process; cellular response to interleukin-1; nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay; histone mRNA catabolic process; dosage compensation by inactivation of X chromosome; cellular response to lipopolysaccharide; 3'-UTR-mediated mRNA destabilization; DNA repair; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of telomere maintenance; cell cycle phase transition; viral process;
	Sources:Amigo / QuickGO
Orthologs
	5976
	19704
	ENSG00000005007
	ENSMUSG00000058301
	Q92900
	Q9EPU0
	NM_002911; NM_001297549
	NM_001122829; NM_030680
	NP_001284478; NP_002902; NP_001284478.1
	NP_001116301; NP_109605
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of nonsense transcripts 1 (or Up-frameshift suppressor 1 homolog^[5]) is a protein that in humans is encoded by the UPF1 gene.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000005007 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058301 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "UniProt". www.uniprot.org. Retrieved 2024-09-28.
^ Perlick HA, Medghalchi SM, Spencer FA, Kendzior RJ Jr, Dietz HC (November 1996). "Mammalian orthologues of a yeast regulator of nonsense transcript stability". Proc Natl Acad Sci U S A. 93 (20): 10928–32. Bibcode:1996PNAS...9310928P. doi:10.1073/pnas.93.20.10928. PMC 38260. PMID 8855285.
^ Applequist SE, Selg M, Raman C, Jack HM (March 1997). "Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein". Nucleic Acids Res. 25 (4): 814–21. doi:10.1093/nar/25.4.814. PMC 146496. PMID 9064659.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000005007 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058301 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "UniProt". www.uniprot.org. Retrieved 2024-09-28.

[pmid8855285-6] Perlick HA, Medghalchi SM, Spencer FA, Kendzior RJ Jr, Dietz HC (November 1996). "Mammalian orthologues of a yeast regulator of nonsense transcript stability". Proc Natl Acad Sci U S A. 93 (20): 10928–32. Bibcode:1996PNAS...9310928P. doi:10.1073/pnas.93.20.10928. PMC 38260. PMID 8855285.

[pmid9064659-7] Applequist SE, Selg M, Raman C, Jack HM (March 1997). "Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein". Nucleic Acids Res. 25 (4): 814–21. doi:10.1093/nar/25.4.814. PMC 146496. PMID 9064659.

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