UQCRB

UQCRB
Identifiers
Aliases	UQCRB, MC3DN3, QCR7, QP-C, QPC, UQBC, UQBP, UQCR6, UQPC, ubiquinol-cytochrome c reductase binding protein
External IDs	OMIM: 191330; MGI: 1914780; HomoloGene: 38164; GeneCards: UQCRB; OMA:UQCRB - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	96,235,546 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	67,053,442 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; vena cava; ; Epithelium of choroid plexus; ; right auricle; ; renal medulla; ; retinal pigment epithelium; ; apex of heart; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; body of tongue;
	Top expressed in
	right kidney; ; quadriceps femoris muscle; ; muscle tissue; ; skeletal muscle tissue; ; muscle of thigh; ; proximal tubule; ; heart; ; stomach; ; human kidney; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; ubiquinol-cytochrome-c reductase activity;
Cellular component	mitochondrial inner membrane; respirasome; membrane; mitochondrion; mitochondrial respirasome; mitochondrial respiratory chain complex III;
Biological process	aerobic respiration; oxidative phosphorylation; mitochondrial respiratory chain complex III assembly; mitochondrial electron transport, ubiquinol to cytochrome c;
	Sources:Amigo / QuickGO
Orthologs
	7381
	67530
	ENSG00000156467
	ENSMUSG00000021520
	P14927
	Q9D855; Q9CQB4
	NM_001199975; NM_001254752; NM_006294
	NM_026219
	NP_001186904; NP_001241681; NP_006285
	NP_080495
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquinol-cytochrome c reductase binding protein, also known as UQCRB, Complex III subunit 7, QP-C, or Ubiquinol-cytochrome c reductase complex 14 kDa protein is a protein which in humans is encoded by the UQCRB gene. This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156467 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021520 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: UQCRB ubiquinol-cytochrome c reductase binding protein". This article incorporates text from this source, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156467 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021520 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: UQCRB ubiquinol-cytochrome c reductase binding protein". This article incorporates text from this source, which is in the public domain.

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