UTX (gene)

KDM6A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3AVR, 3AVS
Identifiers
Aliases	KDM6A, KABUK2, UTX, bA386N14.2, lysine demethylase 6A
External IDs	OMIM: 300128; MGI: 1095419; HomoloGene: 7586; GeneCards: KDM6A; OMA:KDM6A - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	45,112,779 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	18,146,175 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; bone marrow cells; ; left ovary; ; monocyte; ; skin of abdomen; ; germinal epithelium; ; ectocervix; ; vagina; ; epithelium of colon; ; skin of leg;
	Top expressed in
	zygote; ; secondary oocyte; ; genital tubercle; ; primary oocyte; ; internal carotid artery; ; tail of embryo; ; lacrimal gland; ; Rostral migratory stream; ; maxillary prominence; ; external carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	dioxygenase activity; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; identical protein binding; oxidoreductase activity; chromatin DNA binding; histone H3-tri/di-methyl-lysine-27 demethylase activity; histone demethylase activity; chromatin binding; sequence-specific DNA binding;
Cellular component	nucleoplasm; MLL3/4 complex; histone methyltransferase complex; nucleus;
Biological process	respiratory system process; histone H3-K27 demethylation; multicellular organism growth; embryonic organ development; somite rostral/caudal axis specification; heart morphogenesis; in utero embryonic development; heart development; histone H3-K4 methylation; neural tube closure; positive regulation of gene expression; notochord morphogenesis; neural tube development; mesodermal cell differentiation; canonical Wnt signaling pathway; regulation of gene expression; chromatin remodeling; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	7403
	22289
	ENSG00000147050
	ENSMUSG00000037369
	O15550
	O70546
NM_001291415; NM_001291416; NM_001291417; NM_001291418; NM_001291421;
	NM_021140
	NM_009483; NM_001310444
NP_001278344; NP_001278345; NP_001278346; NP_001278347; NP_001278350;
	NP_066963
NP_001297373; NP_033509; NP_001390300; NP_001390301; NP_001390302;
	NP_001390303; NP_001390304; NP_001390305; NP_001390306; NP_001390307; NP_001390308; NP_001390309; NP_001390310
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene.^[5]^[6]^[7] It belongs to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147050 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037369 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: KDM6A lysine demethylase 6A".
^ Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
^ Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P (April 1998). "The UTX gene escapes X inactivation in mice and humans". Hum. Mol. Genet. 7 (4): 737–42. doi:10.1093/hmg/7.4.737. PMID 9499428.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147050 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037369 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KDM6A lysine demethylase 6A".

[pmid9381176-6] Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.

[pmid9499428-7] Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P (April 1998). "The UTX gene escapes X inactivation in mice and humans". Hum. Mol. Genet. 7 (4): 737–42. doi:10.1093/hmg/7.4.737. PMID 9499428.

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