Uddanam nephropathy is a chronic kidney disease (CKD) that is endemic in the Uddanam region of Andhra Pradesh in India. Nephropathy on an endemic scale was first reported in Andhra Pradesh in the 1990s. In 2015, over 34,000 cases of kidney disease were recorded in the region, and it was estimated that at least 4,500 people had died from it in the last ten years. Its cause has not been found yet, and according to the WHO, it is "the least understood and the least publicized" nephropathy of unknown origin.[1][2]