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| Names | |
|---|---|
| IUPAC name
Uridine 5′-(tetrahydrogen triphosphate)
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| Systematic IUPAC name
O1-{[(2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate | |
| Identifiers | |
| ChEMBL | |
| ECHA InfoCard | 100.000.508 |
| MeSH | Uridine+triphosphate |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C9H15N2O15P3 | |
| Molar mass | 484.141 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Uridine-5′-triphosphate (UTP) is a pyrimidine nucleoside triphosphate, consisting of the organic base uracil linked to the 1′ carbon of the ribose sugar, and esterified with tri-phosphoric acid at the 5′ position. Its main role is as substrate for the synthesis of RNA during transcription. UTP is the precursor for the production of CTP via CTP synthetase.[1] UTP can be biosynthesized from UDP by Nucleoside Diphosphate Kinase after using the phosphate group from ATP.[2][3] UDP + ATP ⇌ UTP + ADP;[4] both UTP and ATP are energetically equal.[4]
The homologue in DNA is thymidine triphosphate (TTP or dTTP). UTP also has a deoxyribose form (dUTP).
- ^ Meisenberg, Gerhard Meisenberg (2017). Principles of Medical Biochemistry. Philadelphia, PA, USA: Elsevier. p. 505. ISBN 978-0-323-29616-8.
- ^ Victor, Rodwell (2015). Haper's illustrated Biochemistry. USA: McGraw-Hill. p. 118. ISBN 978-0-07-182537-5.
- ^ Meisenberg, Gerhard Meisenberg (2017). Principles of MEDICAL BIOCHEMISTRY, 4th edition. Philadelphia, PA, USA: Elsevier. p. 59. ISBN 978-0-323-29616-8.
- ^ a b Voet, Donald (2011). Biochemistry, 4th edition. USA: JOHN WILEY & SONS, INC. p. 645. ISBN 978-0-470-57095-1.